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Title:
PRODUCTION OF MORANOLINE DERIVATIVE
Document Type and Number:
Japanese Patent JPS62242692
Kind Code:
A
Abstract:

PURPOSE: To easily obtain the titled compound useful as a remedy for diabetes, etc., in high purity and yield, by carrying out fractional crystallization of a mixture of specific glucosylmoranoline, oligoglucosylmoranoline and moranoline using methanol as a crystallization solvent.

CONSTITUTION: An aqueous solution containing moranoline of formula I and cyclodextrin or soluble starch is successively treated with cyclodextrin glucosyl transferase and glucoamylase. The obtained mixture of glucosylmoranoline of formula II, oligoglucosylmoranoline of formula III (n is 1W5) and the compound of formula I is dissolved in water and the obtained solution is added with methanol. The mixture is stirred preferably at an agitation rate of about 200rpm for 24hr to effect the crystallization and obtain the objective compound which is a molecular compound of methanol and the compound of formula II. Methanol can be removed from the molecular compound by the fractional crystallization using ethanol as the crystallization solvent.


Inventors:
EZURE YOJI
YAMAMOTO MASASHI
MARUO SHIGEAKI
SUGIYAMA MAKOTO
Application Number:
JP8750986A
Publication Date:
October 23, 1987
Filing Date:
April 15, 1986
Export Citation:
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Assignee:
NIPPON SHINYAKU CO LTD
International Classes:
A61K31/70; A61K31/7042; A61K31/7052; A61P3/08; A61P3/10; C07H17/02; (IPC1-7): A61K31/70; C07H3/04
Domestic Patent References:
JPS61115093A1986-06-02