Title:
PRODUCTION OF N-ACETYL-DL-TRYPTOPHAN
Document Type and Number:
Japanese Patent JP3229658
Kind Code:
B2
Abstract:
PURPOSE: To obtain this compound in a high quality and in a high yield by producing N-acetyl-L-tryptophan in a high quality in a high yield in an improved acetylation reaction rate while reducing the by-production of impurities, and subsequently racemizing the produced N-acetyl-L-tryptophan in a homogeneous state.
CONSTITUTION: The method for producing the N-acetyl-DL-tryptophan from L-tryptophan is characterized by simultaneously adding acetic anhydride and an alkali metal hydroxide aqueous solution to the aqueous solution of the L- tryptophan and an alkali metal hydroxide in the substantially same molar amount as that of the L-tryptophan while maintaining the pH of the aqueous solution to 11 or higher, heating the aqueous solution of the acetylation product, and further treating the heated aqueous solution with acetic anhydride.
Inventors:
Seiki Nagahara
Ryuichi Mita
Nobuhiro Fukuhara
Ryuichi Mita
Nobuhiro Fukuhara
Application Number:
JP21016192A
Publication Date:
November 19, 2001
Filing Date:
August 06, 1992
Export Citation:
Assignee:
Mitsui Chemicals, Inc.
International Classes:
C07D209/26; (IPC1-7): C07D209/26