Title:
PRODUCTION OF N-T-BUTYLAMIDE
Document Type and Number:
Japanese Patent JP2531935
Kind Code:
B2
Abstract:
PURPOSE: To obtain the subject compound for e.g. the treatment of infections caused by retroviruses such as HIV industrially advantageously by, for example, a process comprising deductively aminating an isoindol-2-yl-containing α- hydroxyaldehyde compound.
CONSTITUTION: The purpose N-t-butylamide represented by formula IV and being useful, for example, as medicines suited for the treatment of viral infections, especially infections caused by HIV(human immunodeficiency viruses) and other retroviruses is obtained by reductively aminating (2S,3S)-3-(1,3- dioxo-2,3-dihydro-1H-isoindol-2-yl)-2-hydroxy-4-phenylbutyraldehyde of formula I with N-t-butyldecahydro(4aS,8aS)isoquinoline-3(S)-carboxamide or by reacting a 1,3,2-dioxathiolane derivative of formula III (wherein X is SO or SO2) with a compound of formula II.
Inventors:
HANSU HIRUPAATO
Application Number:
JP18043394A
Publication Date:
September 04, 1996
Filing Date:
July 11, 1994
Export Citation:
Assignee:
HOFFMANN LA ROCHE
International Classes:
A61P31/12; C07D209/48; C07D401/06; A61K31/47; C07D411/04; C07D411/06; (IPC1-7): C07D401/06; A61K31/47; C07D209/48
Domestic Patent References:
| JP3251563A |
Attorney, Agent or Firm:
Heiyoshi Odashima
Previous Patent: 発泡シール材
Next Patent: PHARMACEUTICAL COMPOSITION FOR PREVENTION AND TREATMENT OF PREMATURE EJACULATION
Next Patent: PHARMACEUTICAL COMPOSITION FOR PREVENTION AND TREATMENT OF PREMATURE EJACULATION