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Title:
PRODUCTION OF NITROPHTHALIDE
Document Type and Number:
Japanese Patent JPS62479
Kind Code:
A
Abstract:

PURPOSE: To obtain nitrophthalides under mild conditions with good controllability of reaction, by reacting specific phthalides with nitric acid in a nitroalkane or haloalkane.

CONSTITUTION: Phthalides expressed by formula I (R1, R2 and R3 represent 1W6C lower alkyl) are reacted with nitric acid in a nitroalkane (nitromethane, etc.) and/or haloalkane (dichloromethane, etc.) to obtain the aimed compound expressed by formula II. 1W40mol, based on 1mol phthalides, conc. nitric acid or fumic nitric acid is used as the nitric acid and the nitroalkane or haloalkane is used in an amount of 1W20 times based on the phthalides.

USE: An intermediate for producing tritoqualine having action such as antiallergic action, etc.


Inventors:
TANIGUCHI SEIRO
MORITA YOSHIMI
HAYAKAWA SHUZO
TAKEDA YOSHIYUKI
Application Number:
JP13833785A
Publication Date:
January 06, 1987
Filing Date:
June 25, 1985
Export Citation:
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Assignee:
MITSUBISHI CHEM IND
International Classes:
C07D307/88; (IPC1-7): C07D307/88
Attorney, Agent or Firm:
Hajime Hasegawa



 
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