Title:
PRODUCTION OF NNACYL DERIVATIVES OF GLYCINE SUBSTITUTED AT ALPHAAPOSITION BY NOVEL AROMATIC GROUP
Document Type and Number:
Japanese Patent JPS5236643
Kind Code:
A
Abstract:
This is an improved process of manufacturing N-acyl derivatives of glycines alpha -substituted by radicals with an aromatic nature by condensation of the addition product of glyoxylic acid and an amide, with an aromatic compound. In a first stage, the reaction is carried out at low temperature, in a concentrated sulfuric medium, of an aliphatic nitrile of the formula R-C 3BOND N in which R is a radical selected from the group of substituted and unsubstituted, saturated and unsaturated alkyl radicals, with a concentrated aqueous solution of glyoxylic acid. Then in a second stage, the mixture obtained is condensed also at low temperature with a compound of aromatic nature not including a hydroxyl group and having at least one substitutable free hydrogen, and the resulting product is collected. The concentrated sulfuric acid may be supplemented with acetic acid during the second stage. A surface active agent may be also added in this stage. The products are valuable intermediates for the preparation of semi-synthetic penicillins.
Inventors:
YAN KURISUTEIDEI
ARAN SHIYUTEETEN
ARAN SHIYUTEETEN
Application Number:
JP10837176A
Publication Date:
March 22, 1977
Filing Date:
September 08, 1976
Export Citation:
Assignee:
NOBEL HOECHST CHIMIE
International Classes:
C07D333/24; C07C67/00; C07C231/00; C07C231/06; C07C231/08; C07C231/12; C07C233/45; C07C233/47; C07C233/49; (IPC1-7): C07C101/04; C07C102/08; C07C103/30; C07D333/24