Title:
PRODUCTION OF NOVEL LACTONE DERIVATIVES OF CYCLOPENTANOL AND PHARMACEUTICAL COMPOSITION
Document Type and Number:
Japanese Patent JPS52113956
Kind Code:
A
Abstract:
The compounds of formula: are prepared from corresponding carboxylic acids of formula: by a reaction capable of converting the carboxyl group to a functional derivative. The meaning of the symbols is given in Claim 1. Of the compounds obtained, those which have a 15-tetrahydropyranyloxy group can be hydrolysed, those which have a hydroxyl group can be esterified, and those which have a secondary alcohol group in position 15 can be oxidised to the corresponding ketone or dehydrated in position 15, 16; finally, the double bond in position 13, 14 and the triple bond of an alkynyl group in position 15 can be hydrogenated. The compounds display a hypotensive activity; they can be employed in the treatment of hypertension (high blood pressure) and of circulatory disorders.
Inventors:
JIYAN BIYUANDEIA
MISHIERU BIBA
MISHIERU BIBA
Application Number:
JP2981777A
Publication Date:
September 24, 1977
Filing Date:
March 19, 1977
Export Citation:
Assignee:
ROUSSEL UCLAF
International Classes:
A61K31/337; A61K31/34; C07D307/93; A61K31/343; A61K31/365; A61P9/12; A61P43/00; C07D213/82; C07D305/14; C07D307/935; C07D309/12; C07D311/94; C07D407/12; C07D313/06; (IPC1-7): C07D307/93; A61K31/34