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Title:
PRODUCTION OF ODD CHAIN FATTY ACID DERIVATIVES IN RECOMBINANT MICROBIAL CELLS
Document Type and Number:
Japanese Patent JP2022043100
Kind Code:
A
Abstract:
To provide recombinant microbial cells engineered to produce fatty acid derivatives having linear chains containing an odd number of carbon atoms by the fatty acid biosynthetic pathway, and to provide methods for making odd chain fatty acid derivatives using the recombinant microbial cells, and compositions comprising odd chain fatty acid derivatives produced by such methods.SOLUTION: According to the present invention, a recombinant microbial cell comprises polynucleotides respectively encoding a polypeptide having enzymatic activity effective to produce an increased amount of propionyl-CoA, a polypeptide having β-ketoacyl-ACP synthase activity that utilizes propionyl-CoA as a substrate, and a polypeptide having fatty acid derivative enzyme activity. Here, the recombinant microbial cell produces a fatty acid derivative composition comprising odd chain fatty acid derivatives when cultured in the presence of a carbon source under conditions effective to express the polynucleotides, and at least 10% of the fatty acid derivatives in the fatty acid derivative composition are odd chain fatty acid derivatives.SELECTED DRAWING: None

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Inventors:
GRACE J LEE
JOHN R HALIBURTON
HU ZHIHAO
ANDREAS W SCHIRMER
Application Number:
JP2021195994A
Publication Date:
March 15, 2022
Filing Date:
December 02, 2021
Export Citation:
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Assignee:
GENOMATICA INC
International Classes:
C12N1/21; C12N1/15; C12N1/19; C12N5/10; C12N15/54; C12P7/64
Domestic Patent References:
JP2011510611A2011-04-07
Other References:
JAOCS, vol. 68, no. 4, JPN6015048513, 1991, pages 254 - 258, ISSN: 0004917398
ANIMAL FEED SCIENCE AND TECHNOLOGY, vol. Vol. 131, No. 3-4, JPN6015048519, 2006, pages 389 - 417, ISSN: 0004917399
J. BIOL. CHEM., vol. 271, no. 18, JPN6015048523, 1996, pages 10996 - 11000, ISSN: 0004917400
BIOTECHNOL. LETT., vol. 27, no. 18, JPN6015048525, 2005, pages 1381 - 1386, ISSN: 0004917401
Attorney, Agent or Firm:
Shimizu Hatsushi
Masao Haruna
Hirotaka Yamaguchi
Shun Jinbe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Kazuya Kawamoto



 
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