To obtain an oligomer useful as a synthetic vaccine against influenza pathogen by removing protecting group(s) from a specific compound, combining the unmasked compound with a repeating unit, followed by terminating the polymerization with a polymerization terminator.
This oligomer is obtained by binding a compound shown by formula I (R1 is a first protecting group; R2 is a second protecting group) to a solid polyethyleneglycol monoethylether (PEG) carrier, removing the first protecting group, binding the obtained compound to a repeating unit to elongate the side chain shown by formula II, removing a protecting group from the phosphorous atom, repeating the steps comprising removing the first protecting group and binding the product with the repeating unit until the number of an oligomer repeating unit becomes a specific number, followed by terminating the polymerization with a polymerization terminator shown by formula III ((m) is an integer; R3 is a third protecting group which gives a PEG bond protecting oligomer). Preferably, the PEG bond protecting oligomer is released from the carrier to give a compound shown by formula IV ((n) is an integer; X+ is a counter ion).
KANDIL ALI
SIA CHARLES
KLEIN MICHEL H
