Title:
PRODUCTION OF OPTICALLY ACTIVE 1-AMINOPHOSPHONIC ACID DERIVATIVE, PRODUCTION OF CATALYST FOR ASYMMETRIC SYNTHESIS AND NEW PHOSPHONATE-BASED COMPOUND
Document Type and Number:
Japanese Patent JP3574715
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To obtain the subject optically active compound useful as a catalyst for an asymmetric synthesis, etc., by a simple operation in a large amount by reacting a specific imine with a phosphonic acid ester in the presence of the catalyst for the asymmetric synthetsis, bringing the reaction product into contact with acid to deprotect the amino group.
SOLUTION: An imine of formula I [R1 is diphenylmethyl or an alkoxyphenyl; R2 is an alkyl, a cycloalkyl, an aryl group-containing hydrocarbon or a (substituted) aryl] is reacted with a phosphonic acid ester of formula II (R3 is an alkyl, a cycloalkyl, allyl, an aryl or an aryl group-containing hydrocarbon) in the presence of a catalyst for the asymmetric synthetsis shown by formula III (Lu is a rare earth element; X is an alkali metal) to synthesize a phosphonate-based compound, then bringing the product into contact with an acid or hydrogen to deprotect the amino group and further hydrolyzing the OR3 group to give the objective optically active 1-aminophosphonic acid derivative of formula IV or formula V.
Inventors:
Masakatsu Shibasaki
Hiroaki Sasai
Yoshihiro Tahara
Hiroaki Sasai
Yoshihiro Tahara
Application Number:
JP25519596A
Publication Date:
October 06, 2004
Filing Date:
September 26, 1996
Export Citation:
Assignee:
Hokuko Chemical Industry Co., Ltd.
International Classes:
B01J31/22; C07B61/00; C07F9/38; C07F9/40; (IPC1-7): C07F9/38; C07F9/40
Other References:
Synlett,1993年,No.1,p.35-36
Attorney, Agent or Firm:
Shunichiro Suzuki