Title:
PRODUCTION OF OPTICALLY ACTIVE 1-PHENYLETHYLAMINE
Document Type and Number:
Japanese Patent JP3284607
Kind Code:
B2
Abstract:
PURPOSE: To optically resolve (RS)-1-phenylethylamine in high yield and in high optical purity by using a specific resolving agent such as optically active N-formylphenylglycine obtainable from an inexpensive raw material and reusable.
CONSTITUTION: (RS)-1-Phenylethylamine is optically resolved by using a compound selected from optically active N-formylphenylglycine, an optically active tartaric acid anilide derivative of the formula (R is methoxy or nitro) and optically active N-benzoylmethionine as an optically resolving agent to give optically active 1-formylphenylamine. The resolving agent such as optically active N-p-nitrobenzoylalanine is obtained in high yield by reacting a basic aqueous solution of alanine with p-nitrobenzoyl chloride and precipitating with an acid. The resolving agents used are slightly soluble, can be recovered from a solution of diastereomer salt in high yield and decomposition and racemization hardly occur in the recovery process.
Inventors:
Sakie Nakai
Haruyo Sato
Haruyo Sato
Application Number:
JP26042392A
Publication Date:
May 20, 2002
Filing Date:
September 30, 1992
Export Citation:
Assignee:
Toray Industries, Inc.
International Classes:
C07B57/00; C07C209/88; C07C211/27; (IPC1-7): C07C209/88; C07C211/27
Domestic Patent References:
| JP2306942A | ||||
| JP5626848A | ||||
| JP23627A | ||||
| JP4108766A | ||||
| JP3223236A | ||||
| JP617238A | ||||
| JP4108773A |
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