Title:
PRODUCTION OF OPTICALLY ACTIVE 2-METHYLBUTANOIC ACID AND DERIVATIVE THEREOF
Document Type and Number:
Japanese Patent JPH07206756
Kind Code:
A
Abstract:
PURPOSE: To enable the mass production of (S) and (R) isomers of an alkyl methylbutanoate in high optical purity by effecting the optical resolution using an enzyme which can hydrolyze alkyl methylbutanoate in high optical selectivity.
CONSTITUTION: An enzyme which can hydrolyze the substrate in high optical selectivity (from Aspergillus oryzae, Aspergillus malleus, Bacillus subtilis, Bacillus amyloliquefaciens) and/or a microorganism producing such enzyme (Serratia marcescens) are allowed to act on an alkyl methylbutanoate or an alkoxyalkyl 2-methylbutanoate to effect the resolution into optically active (S)-2-methyl- butanoic acid, (R)-alkyl 2-methylbutanoate or (R)-alkoxyalkyl 2-methylbutanoate.
Inventors:
KAMIYAMA TOSHIHARU
OTSUKA KOTARO
NONOGUCHI YASUSHI
MIURA CHIE
OTSUKA KOTARO
NONOGUCHI YASUSHI
MIURA CHIE
Application Number:
JP746894A
Publication Date:
August 08, 1995
Filing Date:
January 27, 1994
Export Citation:
Assignee:
NAGASE & CO LTD
International Classes:
C12P41/00; C07B53/00; C07C29/136; C07C31/125; C07C51/09; C07C53/126; C12R1/07; C12R1/125; C12R1/43; C12R1/66; C12R1/69; (IPC1-7): C07C53/126; C07C51/09; C12P41/00
Attorney, Agent or Firm:
Yoshihiro Tsunoda