To obtain an optically active am-noalcohol useful as an intermediate for a medicine or an agrochemical agent, an asymmetric source in an asymmetric synthesis, etc., by asymmetrically reducing a corresponding ketoxime.
The optically active aminoalcohol of formula III is obtained by an asymmetrical reduction by effecting a syn-compound, an anti-compound or a mixture of an excess of either one of them of ketoxime ethers of formula II (R1, R2 are each independently an aralkyl, a halogen, phenyl, etc.; R3 is an alkyl, an aralkyl, etc.) and an acid with a mixture of a borane compound obtained from an optically active 2-hydroxyethylamine of formula I (R4, R5 are each independently H, an alkyl, phenyl, etc.; R6 is an alkyl, a halogen phenyl, etc.) with a boron metal hydride and an acid, and the boron metal hydride.
KOMEYOSHI YUKIO
SUZUKAMO TAKEO
