To efficiently synthesize the subject compounds useful as an intermediate for producing medicines, etc., by reacting a silyl enol ether with an imine in the presence of a specific catalyst.
A silyl enol ether represented by formula I [R1 is a substituted silyl; R2 is a (substituted) alkyl, a (substitute) alkenyl or the like; R3 and R4 are each H, a (substituted) alkyl, a (substituted) alkenyl or the like] is reacted with an imine represented by formula II [R5 is a (substituted) alkyl, a (substituted) alkenyl or the like; R6 is H, a (substituted) alkyl, a (substituted) alkenyl or the like] in the presence of a catalyst comprising a palladium- optically active phosphine ligand to afford the objective compounds represented by formula III. In the above reaction, e.g. N,N-dimethylformamide is preferably used as a solvent and the reaction is preferably carried out in the presence of a base such as calcium carbonate at a reactional temperature within the range of ambient temperature to 70°C.
HAGIWARA EMIKO
FUJII AKIO
