To easily obtain the subject compound in a good yield by reacting an optically active glycidyl alcohol compound as a starting raw material with biphenyl acetic acid.
An optically active glycidyl alcohol derivative of formula I (R is an OH-protecting group; * is the position of an asymmetric carbon atom) is reacted with diphenyl acetic acid and subsequently subjected to an intermolecular dehydration reaction to obtain a 4,5-dihydro-2(3H)-furanone derivative of formula II. The OH-protecting group of the compound of formula II is released to obtain the optically active 4,5-dihydro-5-hydroxymethyl-3, 3- diphehnyl-2(3H)-furanone of formula III. The compound of formula III is useful as an intermediate for synthesizing an N-substituted-5-aminomethl-3,3-biphenyl-2(3 H)-furanone derivative having an antimuscarine action and useful as a medicine.
TORIYAMA KAZUHIRO
TAISHO PHARMACEUTICAL CO LTD