Title:
PRODUCTION OF OPTICALLY ACTIVE SECONDARY ALCOHOL
Document Type and Number:
Japanese Patent JP3874035
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To produce an optically active secondary alcohol useful as a raw material for pharmaceuticals and agrochemical and a raw material for functional materials such as liquid crystal in high productivity by asymmetrically transesterifying a racemic secondary alcohol with a lipase under specific condition, thereby performing the optical resolution of the racemic compound.
SOLUTION: A racemic secondary alcohol expressed by the formula CH3CH (OH)-(CH2)mR ((m) is an integer of 2-8; R is H or a ≤4C alkyloxy) is optically resolved by an asymmetric transesterification comprising the reaction with vinyl propionate in the presence of a lipase originated from Candida antarcica to effect the selective conversion of the R isomer into a propionic acid ester. the amount of the vinyl ester can be decreased by this process.
Inventors:
Hagiwara Inao
Tomoyuki Yui
Tomoyuki Yui
Application Number:
JP16581396A
Publication Date:
January 31, 2007
Filing Date:
June 26, 1996
Export Citation:
Assignee:
Mitsubishi Gas Chemical Co., Ltd.
International Classes:
C12P41/00; C07B57/00; C07C31/12; C07C31/125; C07C41/44; C07C43/13; C12R1/72; (IPC1-7): C12P41/00; C07B57/00; C07C31/12; C07C31/125; C07C41/44; C07C43/13; //(C12P41/00; C12R1:72); C07M7:00
Domestic Patent References:
| JP4287689A | ||||
| JP5207881A | ||||
| JP4221364A |
Previous Patent: CATHETER AND METHOD FOR REGULATING POSITION
Next Patent: PRODUCTION OF PURIFIED AQUEOUS HYDROGEN PEROXIDE SOLUTION
Next Patent: PRODUCTION OF PURIFIED AQUEOUS HYDROGEN PEROXIDE SOLUTION