PRODUCTION OF OPTICALLY ACTIVE TRANS-3-SUBSTITUTED GLYCIDIC ACID ESTER

Japanese Patent JP3349086

B2

PROBLEM TO BE SOLVED: To provide the subject compound useful as an intermediate for synthesizing medicinal compounds in a high purity and in a high yield by crystallizing the compound from a solution containing the optically active compound, the other optical isomer and a specific ester and subsequently isolating the crystallized compound.
SOLUTION: This method for producing (A) an optical isomer [for example, (2R,3R)-3-(4-methoxyphenyl)glycidic acid methyl ester] based on the 2,3-asymmetric carbon atoms of a compound of the formula [the ring A is (substituted) benzene ring; R1 is an ester residue] comprises crystallizing the component A from a solution containing the component A, (B) the other optical isomer and (C) an ester whose ester residue alone is different from the component B, preferably in a component A/B molar ratio of 4/6 to 10/1, a component C/B molar ratio of 5/3 to 10/1, until reaching a state that the component B is deposited, when the component C is not contained, but that the component A is deposited but the component B is not deposited, because the component C is contained.

Masakatsu Furui
Toshiyuki Furuya

JP4572398A

November 20, 2002

February 26, 1998

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Tanabe Pharmaceutical Co., Ltd.

C12N9/16; A61K31/55; A61K31/5513; A61K31/554; A61P9/08; A61P9/10; A61P9/12; A61P25/22; C07B57/00; C07C59/11; C07D281/10; C07D301/32; C07D303/48; C12R1/43; (IPC1-7): C07D303/48; C07B57/00; C07C59/11; C07D281/10; C07D301/32; C12N9/16

JP3175995A
JP8259552A

Sota Asahina (1 person outside)

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