PRODUCTION OF PYRANOQUINOLINE DERIVATIVE

Title:

PRODUCTION OF PYRANOQUINOLINE DERIVATIVE

Document Type and Number:

Japanese Patent JPH06293770

Kind Code:

A

Abstract:

PURPOSE: To smoothly obtain the subject compound useful as pharmaceuticals such as antithrombotic agent in an easily purifiable state in high yield by reacting 6-hydroxyquinolin-2-one with an allyl halide and subjecting the reactional product to rearrangement, acylation, oxidation, cyclization and removal of protecting group.

CONSTITUTION: The objective compound of formula VII is produced by carrying out dehydrohalogenation reaction of 6-hydroxyquinolin-2-one with an allyl halide of formula I (X is halogen), subjecting the obtained propenyloxyquinolin-2-one derivative of formula II to rearrangement reaction to obtain the compound of formula III, acylating the compound to form a compound of formula IV (R is acyl), oxidizing the product, cyclizing the produced compound of formula V to a compound of formula VI and finally removing the protecting group.

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Inventors:

HISA HIDEYUKI

Application Number:

JP25743492A

Publication Date:

October 21, 1994

Filing Date:

September 01, 1992

Export Citation:

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Assignee:

KODAMA KK

International Classes:

C07D491/052; (IPC1-7): C07D491/052

Attorney, Agent or Firm:

Nobuo Kaida (2 outside)

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