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Patent Searching and Data


Title:
PRODUCTION OF SACCHARIDE DERIVATIVE
Document Type and Number:
Japanese Patent JPS6419086
Kind Code:
A
Abstract:

PURPOSE: To obtain a saccharide derivative suitable as a raw material for statine homologue useful as an intermediate for enzyme inhibitor industrially and advantageously, by reacting a glucose derivative with a specific Grignard reagent.

CONSTITUTION: A glucose derivative shown by formula I is reacted with a Grignard reagent shown by the formula RMgX (R is alkyl, alkenyl, cycloalkyl, cycloalkylalkyl, aryl or aralkyl; X is Cl, Br or I) preferably in an inert solvent (preferably ethyl ether, THF or benzene) at -78W50°C for 30minW5hr to give the aimed compound shown by formula II. The amount of the Grignard reagent used is preferably 1W3 equivalents based on the compound shown by formula I.


Inventors:
Yanagisawa, Hiroaki
Application Number:
JP1987000174258
Publication Date:
January 23, 1989
Filing Date:
July 13, 1987
Export Citation:
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Assignee:
SANKYO CO LTD
International Classes:
C07H9/04; (IPC1-7): C07H9/04