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Patent Searching and Data


Title:
PRODUCTION OF STABLE AQUEOUS SOLUTION OF VITAMIN K2
Document Type and Number:
Japanese Patent JPS61115046
Kind Code:
A
Abstract:

PURPOSE: To obtain a stable aqueous solution of vitamin K2 storable without causing clouding for a long period, and useful especially as an injection, by dissolving vitamin K2 in water in the presence of refined lanolin and a synthetic solubilization agent.

CONSTITUTION: A stable aqueous solution of vitamin K2 of formula (general name: menatetrenone) can be produced by adding a mixture of a synthetic solubilization agent and refined lanolin (a substance harmless to human body) to vitamin K2 (a fat-soluble vitamin). The synthetic solubilization agent is e.g. a nonionic surfactant such as polyoxyethylene hardened castor oil, sorbitan fatty acid ester, etc., or a solvent such as propylene glycol, etc. The refined lanolin is a substance registered in Japanese Pharmacopeia, allowed to be administered continuously to human body as a base component of ointment or cream, and having a chemical component consisting of a fat-like substance obtained from wool, i.e. was. The amount of the refined lanolin is preferably 20W40wt% of the vitamin K2.


Inventors:
CHIBA MASUO
Application Number:
JP23469284A
Publication Date:
June 02, 1986
Filing Date:
November 07, 1984
Export Citation:
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Assignee:
ITOUYU SEIYAKU KK
International Classes:
C07C46/10; C07C45/00; C07C50/14; C07C67/00; (IPC1-7): C07C46/10; C07C50/14
Attorney, Agent or Firm:
Kasuya