PURPOSE: To obtain the titled substance useful as a cardiac inexpensively in high yield, by reacting a thiazole derivative with a compound such as pyridine and a compound such as 2,2,2-trichloroethyl chloroformate, etc., and reacting the reaction product with sulfur, etc.
CONSTITUTION: A thiazole derivative shown by the formula I (R1 is H, hydroxyl group, lower alkyl, aryl, acyl, amino, lower alkylamino, arylamino, etc.; R2 is H, or lower alkyl) is reacted with a compound shown by the formula A-X1 [A is group shown by the formula II (X is halogen; n is 1W3); X1 is halogen] and a compound shown by the formula R3-H (R3 is nitrogen-containing hetero ring residue) at normal pressure under a temperature condition of environment by using preferably equimolar amounts of the compound shown by the formula I and the compound shown by the formula A-X' and ≥ an equimolar amount of the compound shown by the formula R3-H to give a compound shown by the formula III (R3' is dihydro derivative residue of nitrogen-containing hetero ring). Then, this compound is reacted with sulfur, or reacted with zinc and oxidized, to give the aimed compound including a novel compound shown by the formula IV.
YOSHIOKA KIMITOMO
YAMAZAKI HIROSUKE
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