Title:
PRODUCTION OF THIENOTHIOPYRAN DERIVATIVE
Document Type and Number:
Japanese Patent JP3279671
Kind Code:
B2
Abstract:
PURPOSE: To easily obtain the subject compound useful as an antiglaucoma agent, etc., in high yield and efficiency by treating dihydrooxomethylthienothiopyran dioxide with a microorganism belonging to the genus Ambrosiozyma, etc., and reducing the product.
CONSTITUTION: The objective compound of formula II is produced by treating 5,6-dihydro-4-oxo-(S)-6-methyl-thieno[2,3-b]thiopyran-7,7-dioxide of formula I with a microorganism selected from the microorganisms of the group of Ambrosiozyma, Arthroascus, Ashbya, Candida, Cryptococcus, Hansenula, Kluyveromyces, Lipomyces, Lodderomyces, Metschnikowia, Pachysolen, Pichia, Rhodosporidium, Rhodotorula, Saccharomyces, Saccharomycopsis, Schwanniomyces, Sporidiobolus, Sporobolomyces, Stephanoascus, Trigonopsis, Trichosporon and Wingea and reducing the treated product.
Inventors:
Yoshihiko Yasohara
Yoshiko Tasato
Noboru Ueyama
Junzo Hasegawa
Satomi Takahashi
Yoshiko Tasato
Noboru Ueyama
Junzo Hasegawa
Satomi Takahashi
Application Number:
JP25782292A
Publication Date:
April 30, 2002
Filing Date:
September 28, 1992
Export Citation:
Assignee:
Kanegafuchi Chemical Industry Co., Ltd.
International Classes:
A61K31/35; A61P27/02; A61P27/06; C07D495/04; C12P17/18; C12P41/00; C12R1/645; C12R1/72; C12R1/74; C12R1/78; C12R1/84; C12R1/85; C12R1/865; (IPC1-7): C12P17/18
Domestic Patent References:
| JP8501216A |
Attorney, Agent or Firm:
Sota Asahina (1 person outside)