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Title:
PRODUCTION OF TICLOPIDINE
Document Type and Number:
Japanese Patent JPS62205087
Kind Code:
A
Abstract:

PURPOSE: The reduction of (chlorobenzoyl)-tetrahydro-thienopyridine is reduced with sodium borohydride in an acidic dimethylsulfoxide enables the advantageous production of the titled compound which is used as a blood platelet coagulant or a blood platelet adhesion inhibitor.

CONSTITUTION: The reduction of 5-(2-chlorobenzoyl)-4,5,6,7-tetrahydro-thieno[3,2- C]pyridine of formula I is carried out with sodium borohydride, preferably in an amount of 1W4 times the molar quantity of the pyridine in an acidic dimethylsulfoxide to give the objective 5-(2-chlorobenzyl)-4,5,6,7-tetrahydro- thieno[3,2-C]pyridine. The acidic dimethylsulfoxide is prepared by adding methanesulfonic acid, ethanesulfonic acid, benzenesulfonic acid or p- toluenesulfonic acid.


Inventors:
YAMANOCHI TAKENAGA
Application Number:
JP4641786A
Publication Date:
September 09, 1987
Filing Date:
March 05, 1986
Export Citation:
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Assignee:
ASAHI CHEMICAL IND
International Classes:
C07D495/04; (IPC1-7): C07D495/04
Attorney, Agent or Firm:
Takeshi Shimizu



 
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