Title:
画像解析による固形腫瘍進行の予後検査
Document Type and Number:
Japanese Patent JP5866362
Kind Code:
B2
Abstract:
The present invention relates to a method for the prognosis of the progression of a solid tumour in a patient, which includes at least the following steps: a) making, from a tumour sample, a virtual slide on which a tumour front can be identified; b) quantifying, on said virtual slide made in step a), the density of cells and/or blood vessels present in a continuous area covering the tumour front and extending on either side of the tumour front over a distance of at least 0.5 mm, referred to as the quantification area; and c) deducing, from said quantification, the risks of postoperative relapse and/or the sensitivity to various antitumor treatments and/or the risks of developing metastases in said patient. Preferably, the cells to be quantified are leukocytes, such as T cells, B cells, macrophages, natural killer cells, dendritic cells, or subpopulations of these immune system cells.
Inventors:
Jean-Francois, Emile
Marc-Antoine, Arard
Marc-Antoine, Arard
Application Number:
JP2013527625A
Publication Date:
February 17, 2016
Filing Date:
September 09, 2011
Export Citation:
Assignee:
UNIVERSITE DE VERSAILLES-ST QUENTIN EN YVELINES
ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS
ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS
International Classes:
G01N33/574; G01N21/27; G01N33/48; G01N33/483; G01N33/53
Domestic Patent References:
| JP2009515148A | ||||
| JP2011518768A | ||||
| JP7503069A | ||||
| JP2006517663A | ||||
| JP2006215165A |
Other References:
Lancet Oncol 2009; 10: 877-884
Attorney, Agent or Firm:
Hirohito Katsunuma
Yukitaka Nakamura
Noritaka Yokota
Hiroshi Morita
Yukitaka Nakamura
Noritaka Yokota
Hiroshi Morita