Title:
プロキネチシンポリペプチド、関連組成物および方法
Document Type and Number:
Japanese Patent JP2004532609
Kind Code:
A
Abstract:
The invention provides isolated polypeptides that stimulate gastroeintestinal smooth muscle contraction, including human prokineticin 1 and human prokineticin 2 polypeptides, and functional fragments and modifications thereof. Also provided are methods of stimulating gastrointestinal smooth muscle contraction in a mammal, by administering to the mammal an effective amount of a prokineticin polypeptide. The invention also provides nucleic acid molecules encoding a prokineticin polypeptide, and antibodies that selectively bind a prokineticin polypeptide. Further provided are methods of identifying a prokineticin receptor ligand, agonist or antagonist.
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Inventors:
Elephant, Khun-Young
Eurat, Frederick Jay.
Eurat, Frederick Jay.
Application Number:
JP2002539383A
Publication Date:
October 28, 2004
Filing Date:
November 01, 2001
Export Citation:
Assignee:
The Regent of the University of California
International Classes:
G01N33/50; A61K38/00; A61P1/00; A61P29/00; A61P31/00; A61P35/00; C07K14/47; C07K16/18; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12N15/12; C12P21/02; C12Q1/02; G01N33/15; G01N33/53; G01N33/566; A61K39/00; (IPC1-7): C12N15/09; A61K38/00; A61P1/00; A61P29/00; A61P31/00; A61P35/00; C07K14/47; C07K16/18; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/02; C12Q1/02; G01N33/15; G01N33/50; G01N33/53; G01N33/566
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita