Title:
PROMOTER FOR MODULATING EXPRESSION OF AGGRECANASE 1 (ADAMTS4)
Document Type and Number:
Japanese Patent JP2001245663
Kind Code:
A
Abstract:
To construct a system for screening a compound which controls the transcription of aggrecanase 1 gene related to various diseases, clones a promoter domain, elucidates a base sequence and affects the expression of aggrecanase 1.
A base sequence of a promoter domain at the upstream of an aggrecanase 1 gene is elucidated, a vector in which a reporter gene is connected to the downstream of the promoter domain of the aggrecanase 1 gene or a promoter domain deficient in a part of the promoter gene is prepared, transferred to a mammalian cell and the compound affecting the expression of aggrecanase 1 can be screened.
Inventors:
YAMAZAKI KAZUTO
MIZUI YOSHIHARU
KUBOI YOSHIKAZU
MIZUI YOSHIHARU
KUBOI YOSHIKAZU
Application Number:
JP2000059952A
Publication Date:
September 11, 2001
Filing Date:
March 06, 2000
Export Citation:
Assignee:
EISAI CO LTD
International Classes:
C12N15/09; A61K45/00; A61P19/02; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12Q1/00; C12Q1/42; (IPC1-7): C12N15/09; A61K45/00; A61P19/02; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12Q1/00; C12Q1/42