Title:
PROMOTERS EXHIBITING ENDOTHELIAL CELL SPECIFICITY AND METHODS OF USING SAME FOR REGULATION OF ANGIOGENESIS
Document Type and Number:
Japanese Patent JP2015057057
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide nucleic acid constructs, pharmaceutical compositions, and methods which can be used to regulate angiogenesis in specific cell regions.SOLUTION: The invention relates to a modified-preproendothelin-1 (PPE 1) promoter which exhibits increased activity and specificity in endothelial cells, and a nucleic acid construct which can be used to either activate cytotoxicity in specific cell subsets, thus, enabling treatment of diseases characterized by aberrant neovascularization or cell growth, or induce the growth of new blood vessels, thus, enabling treatment of ischemic diseases. The invention further relates to modifications of the PPE promoter, which enhance its expression in response to physiological conditions including hypoxia and angiogenesis, as well as novel angiogenic endothelial-specific combined therapies.
Inventors:
HARATS DROR
GREENBERGER SHOSHANA
BREITBART EYAL
BANGIO LIVNAT
PELED MICHAEL
GREENBERGER SHOSHANA
BREITBART EYAL
BANGIO LIVNAT
PELED MICHAEL
Application Number:
JP2014205463A
Publication Date:
March 26, 2015
Filing Date:
October 06, 2014
Export Citation:
Assignee:
VASCULAR BIOGENICS LTD
International Classes:
C12N15/09; A61K35/74; A61K35/76; A61K38/17; A61K48/00; A61P9/00; A61P9/10; A61P17/06; A61P19/02; A61P35/00; A61P35/04; C07K14/475; C07K14/515; C07K14/575; C12N5/10; C12N7/00; C12N15/85; C12N15/861
Domestic Patent References:
| JP2003534806A | 2003-11-25 | |||
| JP2003527128A | 2003-09-16 | |||
| JP2002507382A | 2002-03-12 |
Foreign References:
| WO2003093409A2 | 2003-11-13 | |||
| WO2004061458A2 | 2004-07-22 | |||
| WO2003039458A2 | 2003-05-15 |
Other References:
JPN6011028135; Ｊ． Ｃｌｉｎ． Ｉｎｖｅｓｔ． ｖｏｌ．９５, 1995, ｐｐ．１３３５-１３４４
Attorney, Agent or Firm:
Nobuaki Kazahaya
Noriko Asano
Noriko Asano