PROMOTION OR INHIBITION OF ANGIOPLASTY AND CARDIOVASCULAR NEOGENESIS

Title:

PROMOTION OR INHIBITION OF ANGIOPLASTY AND CARDIOVASCULAR NEOGENESIS

Document Type and Number:

Japanese Patent JP2004154140

Kind Code:

A

Abstract:

To provide a composition and a method for stimulation or inhibition of angiogenesis and/or cardiovascular plasty in mammals including human beings.

A pharmaceutical composition based on polypeptides or antagonists thereof identified in terms of one or a plurality of these usages is provided. Diseases which are diagnosed, prevented or treated with the composition comprises injury such as wound, various cancers, and vascular diseases including atherosclerosis and cardiac hypertrophy. In addition, this invention provides novel polypeptides and a nucleic acid molecule encoding these polypeptides. Moreover, a vector and host cell including these nucleic acid sequences, a chimeric polypeptide molecule including these polypeptides fused with a different kind of polypeptide, an antibody binding to these polypeptides, and a method for producing these polypeptides are provided.

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Inventors:

ASHKENAZI AVI J
BAKER KEVIN P
FERRARA NAPOLEONE
GERBER HANSPETER
GERRITSEN MARY E
GODDARD AUDREY
GURNEY AUSTIN L
HILLAN KENNETH J
MARSTERS SCOT A
PAONI NICHOLAS F
PITTI ROBERT M
WATANABE COLIN K
WILLIAMS P MICKEY
WOOD WILLIAM I

Application Number:

JP2003420475A

Publication Date:

June 03, 2004

Filing Date:

December 18, 2003

Export Citation:

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Assignee:

GENENTECH INC

International Classes:

G01N33/50; A61K31/7088; A61K38/00; A61K38/17; A61K39/395; A61K45/00; A61K45/06; A61K48/00; A61P9/00; A61P9/04; A61P9/10; A61P17/00; A61P17/02; A61P27/02; A61P35/00; A61P43/00; C07K14/47; C07K14/705; C07K16/18; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N7/00; C12N15/09; C12N15/12; C12N15/62; C12P21/02; C12P21/08; C12Q1/02; C12Q1/68; G01N33/15; G01N33/53; (IPC1-7): C12N15/09; A61K31/7088; A61K38/00; A61K39/395; A61K45/00; A61K45/06; A61K48/00; A61P9/00; A61P9/10; A61P17/00; A61P17/02; A61P35/00; A61P43/00; C07K14/47; C07K16/18; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N7/00; C12P21/02; C12P21/08; C12Q1/02; C12Q1/68; G01N33/15; G01N33/50

Other References:

JPN6009065829, ＦＥＢＳ　Ｌｅｔｔ．，Ｖｏｌ．４２２，Ｎｏ．１（１９９８）ｐ．２７−３２
JPN6009065828, Ｊ．Ｂｉｏｌ．Ｃｈｅｍ．，Ｖｏｌ．２７２，Ｎｏ．５１（１９９７）ｐ．３２５３４−３２５３８

Attorney, Agent or Firm:

Sonoda Yoshitaka
Kobayashi Yoshinori

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