To find a compound useful as a prophylactic or therapeutic agent for optical nerve disorders, an inhibitor of the death of retinal ganglion cells or an agent for recovering the expression level of a neurofilament light chain, particularly a compound which can exhibit the physiological activity by oral administration.
3',5-Di-2-propenyl-(1,1'-biphenyl)-2,4'-diol, an ester thereof, or salts thereof can significantly prevent the reduction in the number of cells in a retinal ganglion cell layer in an NMDA-induced retinal disorder model rat when administered orally to the model rat and can recover the reduction in the expression level of a neurofilament light chain in a retina in the model rat when administered intravitreally to the model rat. Therefore, the compound, the ester or the salt is useful as a prophylactic or therapeutic agent for optical nerve disorders, an inhibitor of the death of retinal ganglion cells or an agent for recovering the expression level of a neurofilament light chain.
| WO/2003/000243 | ANTIMICROBIAL NANOEMULSION COMPOSITIONS AND METHODS |
| WO/2024/029580 | AUTOPHAGY-ACTIVATION-ACCELERATING COMPOSITION |
| WO/2001/060388 | CELL ACTIVATOR |
SEIKE TOSHIYUKI
KAGEYAMA MASAAKI
Einosuke Kishimoto
Akira Watanabe
Matsumura Naoto