PROPIONIC ACID DERIVATIVE AND ITS PREPARATION

Japanese Patent JPS56108760

A

NEW MATERIAL:A propionic acid derivative of formula I (R1 is methoxyphenyl; R2 is H or lower aliphatic acyl; R3 is H or lower alkyl) or a salt thereof.

EXAMPLE: 2-Hydroxy-3-p-methoxyphenyl-3- [ o-[ 2-( dimethylamino ) ethylamino ] phenyl]thiopropionic acid.

USE: A hypotensive agent.

PROCESS: A 2-hydroxy-3-methoxyphenyl-3-(o-aminophenyl)thio-propionic acid compound of formula II (R4 is a protecting group of the amino group) having the protected amino group is reacted with a dimethylaminoethyl halide of formula III (X1 is halogen) to give a thio-propionic acid compound of formula IV. The protecting group of the amino group is then removed from the compound of formula IV to afford the compound of formula I.

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NAGAO SHIGETO
GAINO MITSUNORI
TAKAMURA NORIO
SATOU MASANORI

JP1183880A

August 28, 1981

February 01, 1980

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TANABE SEIYAKU CO

A61K31/19; A61K31/195; A61K31/215; A61K31/22; A61P9/12; C07C67/00; C07C313/00; C07C323/52; (IPC1-7): A61K31/19; A61K31/215; C07C149/42

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