Title:
PROPIOPHENONE DERIVATIVE AND PRODUCTION THEREOF
Document Type and Number:
Japanese Patent JP3034192
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To obtain a new propiophenone derivative which is a specific propiophenone derivative bearing a benzofuran ring, has excellent hypoglycemic action based on its inhibition of glucose reabsorption in kidney and is useful as a therapeutic and preventive agent for diabetes.
SOLUTION: This novel propiophenone derivative or its salt is represented by formula I [R is formula II (X is 0, a single bond; ring A is a benzene ring, a pyridine ring; Ra is H, a lower alkyl, a lower alkoxy, a halogen; where in the case that the ring A is a benzene ring, Ra is not H)] and shows excellent urinary sugar increase and thus excellent hypoglycemic action based on its inhibition of glucose reabsorption in kidney. In the meanwhile, its aglycon has very weak inhibitory action on the saccharide carrier of a facilitated diffusion type, thus this derivative is useful as a therapeutic and preventive agent for diabetes. This compound is prepared by acylating a compound of formula III with a carboxylic acid of formula IV and, if desired, conversion of the product to its salt.
Inventors:
Kenji Tsujihara
Kunio Saito
Mitsuya Motomiya
Mamoru Matsumoto
Kozo Oka
Kunio Saito
Mitsuya Motomiya
Mamoru Matsumoto
Kozo Oka
Application Number:
JP28848995A
Publication Date:
April 17, 2000
Filing Date:
November 07, 1995
Export Citation:
Assignee:
Tanabe Pharmaceutical Co., Ltd.
International Classes:
C07H15/26; A61K31/70; A61K31/7028; A61K31/7034; A61K31/7048; A61P3/08; A61P3/10; A61P43/00; C07H15/203; (IPC1-7): C07H15/203
Domestic Patent References:
| JP6199886A | ||||
| JP6298790A | ||||
| JP8193093A |
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)
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