Title:
プロポフォール及びスルホアルキルエーテルシクロデキストリン含有製剤
Document Type and Number:
Japanese Patent JP4334229
Kind Code:
B2
Abstract:
An injectable formulation of a sedative hypnotic drug, such as the anesthetic drug etomidate, that is pharmaceutically stable, demonstrates a reduced incidence of pain upon injection, and is bioequivalent with currently approved formulations. The formulation of the present invention employs a sulfoalkyl ether cyclodextrin solubilizing and complexing excipient, such as CAPTISOL(R) cyclodextrin (sulfobutyl ether beta-cyclodextrin) to form a true aqueous solution. This formulation minimizes the allergic response and microbial contamination issues typically associated with parenteral emulsion formulations. The present formulation also reduces pain on injection as compared to the known organic solvent based formulations containing etomidate. The liquid formulation can be sterile filtered unlike emulsion-type formulations of sedative hypnotics. The liquid formulation can be lyophilized or otherwise dried to yield a solid formulation.
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Inventors:
Gerold El Mosher
Diane Oh Thompson
Diane Oh Thompson
Application Number:
JP2002572914A
Publication Date:
September 30, 2009
Filing Date:
March 19, 2002
Export Citation:
Assignee:
Sidex Pharmaceuticals, Inc.
International Classes:
A61K9/08; A61K31/05; A61K31/167; A61K31/245; A61K31/445; A61K31/4453; A61K31/4704; A61K31/724; A61K47/40; A61K47/48; A61P23/02; A61P25/20; C08B37/16
Domestic Patent References:
| JP6511513A | ||||
| JP5504783A |
Foreign References:
| WO1996032135A1 |
Attorney, Agent or Firm:
Chika Takagi
Kosuke Nishimura
Junji Yuda
Shoji Miwa
Kosuke Nishimura
Junji Yuda
Shoji Miwa