Title:
PROSTACYCLINE ANALOGUE
Document Type and Number:
Japanese Patent JPS57109776
Kind Code:
A
Abstract:
Prostacyclines of formula: and -C(O)OH wherein R1 is hydrogen or hydroxy, R is C1 to C6 alkyl, or optionally substituted phenyl, wherein the substituents are selected from the group C1 to C4 alkyl, C1 to C4 alkoxy, halo and trifluoromethyl and R16 is C1 to C6 alkyl; C13-C14 is selected from tile group -CH=CH-(trans) and -CM2CH2-; and R2 is selected from the group wherein R6 is C3 to C5 alkyl; R7 is C2 to C4 alkyl; R10 is C1 to C4 alkyl; R11 is C3 to C7 alkyl; R17 is hydrogen, methyl or ethyl; the racemic mixture thereof; the mirror image thereof; and the pharmaceutically acceptable, non-toxic salts thereof; and their intermediates. These compounds are useful as bronchodilators and inflammatory mediator release inhibitors.
Inventors:
CHIYAARUZU BINSENTO GURUJINSUK
SOUUMEI RAI CHIEN
ARAN UISUNAA
SOUUMEI RAI CHIEN
ARAN UISUNAA
Application Number:
JP17911081A
Publication Date:
July 08, 1982
Filing Date:
November 10, 1981
Export Citation:
Assignee:
AMERICAN CYANAMID CO
International Classes:
A61K31/557; A61K31/5575; A61P1/04; A61P7/02; C07D307/935; A61P9/00; A61P9/08; A61P9/12; A61P11/08; C07C67/00; C07C401/00; C07C405/00; C07D307/937; C07D317/04; C07D407/06; C07F7/18; (IPC1-7): A61K31/557; C07C177/00; C07D307/935; C07D407/06