NEW MATERIAL:A prostaglandin I2 analog of formula I: (Y is group of formula II, etc.; R1 is H, 1W12C alkyl group, etc.; R2 is H, methyl group, etc.; R3 is Cl or F; n is an integer 2W8; the 11-and 15-positions are α, β or αβ-configuration, the bond between the 5-and 6-positions is Z), its cyclodextrin clathrate compound, and a non-toxic salt of the acid.
EXAMPLE: (5Z, 13E)-(9α, 11α, 15S)-6,9-Epoxy-11,15-dihydroxy-20-chloroprosta- 5,13-dienic acid methyl ester.
USE: Hypotensives, anti-agglutinating agents for the blood platelet, artery relaxants, suppressants for acid secretion in the stomach and peptic ulcer, myometrium contraction stimulants, and inhibitors for criminal abortion, corpus luteum retraction, and egg implantation.
PROCESS: A compound of formula III: (the double bond between the 5-and 6-positions is cis) is halogenated and cyclized to give a compound of formula IV: (R8 is Br or I), which is dehydrohalogenatd to form the objective compound of formula I.
ARAI YOSHINOBU
OONADA SHIYUUICHI
HASHIMOTO SHINSUKE
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