Title:
プロテアーゼ切断耐性、志賀毒素Ａサブユニットエフェクターポリペプチド及びそれを含む細胞標的化分子
Document Type and Number:
Japanese Patent JP6735237
Kind Code:
B2
Abstract:
The present invention provides protease-cleavage resistant molecules comprising Shiga toxin effector polypeptides capable of exhibiting potent, Shiga toxin functions (e.g. subcellular routing and cytotoxicity). The present invention also provides protease-cleavage resistant, cell-targeted molecules for targeting specific cell types, e.g., infected or malignant cells. Certain molecules of the present invention are cytotoxic, and certain cell-targeted molecules of the present invention may be used for the targeted killing of specific cell types and the treatment of a variety of diseases, disorders, and conditions, including cancers, tumors, growth abnormalities, immune disorders, and microbial infections. Certain cell-targeted molecules of the invention exhibit improved, in vivo tolerability as compared to related cell-targeted molecules comprising protease-cleavage sensitive, wild-type, Shiga toxin effector polypeptides. The cell-targeted molecules of the invention can deliver additional materials, such as, e.g., antigens, cytotoxic agents, and detection-promoting agents, into the interiors of target cells.
Inventors:
Poma Eric
Willat Erin
Higgins Jack
Kim jason
Willat Erin
Higgins Jack
Kim jason
Application Number:
JP2016569950A
Publication Date:
August 05, 2020
Filing Date:
June 10, 2015
Export Citation:
Assignee:
MOLECULAR TEMPLATES, INC.
International Classes:
C12N15/31; A61K31/7088; A61K35/12; A61K35/76; A61K38/16; A61K39/395; A61K47/64; A61P1/04; A61P3/10; A61P5/14; A61P9/00; A61P11/06; A61P17/00; A61P17/06; A61P19/02; A61P25/00; A61P29/00; A61P31/00; A61P31/18; A61P35/00; A61P37/02; A61P37/06; C07K16/18; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12Q1/04
Domestic Patent References:
| JP2002521019A | ||||
| JP5502880A |
Attorney, Agent or Firm:
Masaki Hirota
Seiji Ozawa
Yusaku Tokai
Kazuhiro Matsuda
Makoto Horiuchi
Masako Yamauchi
Shuichi Sonomoto
Akihiro Yamamura
Satoshi Morikawa
Hiroyuki Tomita
Seiji Ozawa
Yusaku Tokai
Kazuhiro Matsuda
Makoto Horiuchi
Masako Yamauchi
Shuichi Sonomoto
Akihiro Yamamura
Satoshi Morikawa
Hiroyuki Tomita