Title:
プロテアーゼ阻害剤
Document Type and Number:
Japanese Patent JP4160615
Kind Code:
B2
Abstract:
[Problems] To provide a novel protease inhibitor and curative remedies and a therapeutic method for chronic obstructive pulmonary disease, immunodeficiency syndrome, alveolar proteinosis and circulatory diseases. [Means for solving problems] A protease inhibitor and a preventive or a remedy for chronic obstructive pulmonary disease or immunodeficiency syndrome characterized by containing at least one member selected from among redox active proteins and genes encoding the same and a preventive or a remedy for chronic obstructive pulmonary disease, alveolar proteinosis or circulatory diseases characterized by containing at least one member selected from IL-18 and a gene encoding the same.
Inventors:
Junji Yodoi
Hajime Nakamura
Tomoaki Hoshino
Aizawa Hisamichi
Hajime Nakamura
Tomoaki Hoshino
Aizawa Hisamichi
Application Number:
JP2006510996A
Publication Date:
October 01, 2008
Filing Date:
March 11, 2005
Export Citation:
Assignee:
Redox Bioscience Co., Ltd.
International Classes:
A61K38/00; A01K67/027; A61K45/00; A61K45/06; A61K48/00; A61P9/00; A61P9/02; A61P11/00; A61P43/00; C07K14/54; C12N9/64; C12N15/09; G01N33/15; G01N33/50
Domestic Patent References:
| JP2005060408A | ||||
| JP2001510997A | ||||
| JP63230637A |
Other References:
中村 肇,チオレドキシンによる炎症制御,THE LUNG Perspective,2002年,Vol.10, No.4,pp445-450
大塚 義紀,COPDの危険因子,医学のあゆみ,2001年,Vol.196, No.9,pp581-586
SANDSTROM, T et al,Allergy and automobile pollution,Revue Francaise d'Allergologie et d'Immunologie Clinique,2000年,Vol.40, No.1,pp47-51
橋本 修,酸化ストレスに対する気道の防御機構:thioredoxin/ADFの発現と酸化ストレスによる急性肺障害の防御効果を中心に,日本気道食道科学会会報,1998年,Vol.49, No.2,pp109-112
HOSHINO,T. et al,Redox-active protein thioredoxin prevents proinflammatory cytokine- or bleomycin-induced lung injury,Am J Respir Crit Care Med,2003年,Vol.168, No.9,p.1075-83
FARINA,A.R. et al,Thioredoxin alters the matrix metalloproteinase/tissue inhibitors of metalloproteinase balance and stimulates human SK-N-SH neuroblastoma cell invasion,Eur J Biochem,2001年,Vol.268, No.2,p.405-13
SEN,C.K.,Redox signaling and the emerging therapeutic potential of thiol antioxidants,Biochem Pharmacol,1998年,Vol.55, No.11,p.1747-58
MACNEE,W. et al,Oxidants and antioxidants as therapeutic targets in chronic obstructive pulmonary disease,Am J Respir Crit Care Med,1999年,Vol.160, No.5 Pt 2,p.S58-65
大塚 義紀,COPDの危険因子,医学のあゆみ,2001年,Vol.196, No.9,pp581-586
SANDSTROM, T et al,Allergy and automobile pollution,Revue Francaise d'Allergologie et d'Immunologie Clinique,2000年,Vol.40, No.1,pp47-51
橋本 修,酸化ストレスに対する気道の防御機構:thioredoxin/ADFの発現と酸化ストレスによる急性肺障害の防御効果を中心に,日本気道食道科学会会報,1998年,Vol.49, No.2,pp109-112
HOSHINO,T. et al,Redox-active protein thioredoxin prevents proinflammatory cytokine- or bleomycin-induced lung injury,Am J Respir Crit Care Med,2003年,Vol.168, No.9,p.1075-83
FARINA,A.R. et al,Thioredoxin alters the matrix metalloproteinase/tissue inhibitors of metalloproteinase balance and stimulates human SK-N-SH neuroblastoma cell invasion,Eur J Biochem,2001年,Vol.268, No.2,p.405-13
SEN,C.K.,Redox signaling and the emerging therapeutic potential of thiol antioxidants,Biochem Pharmacol,1998年,Vol.55, No.11,p.1747-58
MACNEE,W. et al,Oxidants and antioxidants as therapeutic targets in chronic obstructive pulmonary disease,Am J Respir Crit Care Med,1999年,Vol.160, No.5 Pt 2,p.S58-65
Attorney, Agent or Firm:
Kazuhiro Kiyohara