Title:
保護化2’-デオキシシチジン類の精製法
Document Type and Number:
Japanese Patent JP4326841
Kind Code:
B2
Abstract:
A protected 2'-deoxycytidine is purified by precipitating the protected 2'-deoxycytidine represented by general formula (3) in the form of a hydrated crystal from a solution containing the protected 2'-deoxycytidine and water, and by recovering the protected 2'-deoxycytidine: wherein R1 represents a 4-methoxytrityl, 4, 4'-dimethoxytrityl, or triphenylmethyl group; and B1 represents a cytosine group having a protected amino group. The compound represented by general formula (3) may be, in particular, a protected 2'-deoxycytidine represented by formula (4): The 2'-deoxycytidine is used as a raw material for antisense DNA.
Inventors:
Taiki Ishibashi
Kiyoteru Nagahara
Fukuiri Yasushi
Matsuba Yasuko
Kiyoteru Nagahara
Fukuiri Yasushi
Matsuba Yasuko
Application Number:
JP2003158206A
Publication Date:
September 09, 2009
Filing Date:
June 03, 2003
Export Citation:
Assignee:
Mitsui Chemicals, Inc.
International Classes:
C07H19/073; B01D9/02; C07H1/06; C07H19/06
Domestic Patent References:
| JP2002293791A | ||||
| JP2003306496A |
Foreign References:
| WO2000075154A2 |
Attorney, Agent or Firm:
Shinji Hayami
Koji Sato
Koji Sato