タンパク質のリガンド-指向性共有的修飾

Japanese Patent JP2013516422

A

The present invention relates to enzyme inhibitors. More specifically, the present invention relates to ligand-directed covalent modification of proteins; method of designing same; pharmaceutical formulation of same; and method of use.

Russell Sea. Petter
Charles F. Jewell
Quang Holly
Alabind Prasad Medoikonda
Dequiang Niu
LIQUIN QUIAO
Jaswinder Singh
Zheng Dong Zhu

JP2012547291A

May 13, 2013

December 30, 2010

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Avila Therapeutics, Incorporated

C07K5/08; A61K31/05; A61K31/12; A61K31/122; A61K31/137; A61K31/16; A61K31/18; A61K31/215; A61K31/235; A61K31/24; A61K31/265; A61K31/337; A61K31/341; A61K31/343; A61K31/352; A61K31/357; A61K31/365; A61K31/366; A61K31/37; A61K31/381; A61K31/397; A61K31/4015; A61K31/4178; A61K31/42; A61K31/443; A61K31/454; A61K31/47; A61K31/4709; A61K31/496; A61K31/505; A61K31/506; A61K31/519; A61K31/52; A61K31/53; A61K31/5377; A61K31/538; A61K31/5386; A61K38/00; A61P43/00; C07C39/42; C07C47/46; C07C49/573; C07C69/94; C07C205/06; C07C327/16; C07D205/08; C07D207/273; C07D217/04; C07D239/48; C07D261/04; C07D305/12; C07D307/33; C07D307/60; C07D307/77; C07D307/93; C07D311/14; C07D311/76; C07D333/32; C07D333/36; C07D333/38; C07D401/04; C07D401/12; C07D401/14; C07D403/12; C07D405/04; C07D405/12; C07D405/14; C07D409/12; C07D417/14; C07D473/38; C07D487/04; C07D491/147; C07D493/04; C07D495/04; C07D498/08; C07D513/04; C07D519/00; C07K1/13; C12N9/99; G16B15/30

JP2007522116A	2007-08-09
JP2006508997A	2006-03-16

WO2009051822A1	2009-04-23
US20060174816A1	2006-08-10
US20090306085A1	2009-12-10
US20090137588A1	2009-05-28
US20070020684A1	2007-01-25

JPN6015011602; Ｈｕｒ　ｅｔ　ａｌ．: Ｂｉｏｏｒｇａｎｉｃ　＆　Ｍｅｄｉｃｉａｌ　Ｃｈｅｍｉｓｔｒｙ　Ｌｅｔｔｅｒｓ Ｖｏｌ．１８，　Ｎｏ．２２, ｐ．５９１６-５９１９（２００８）
JPN6015011607; Ｙａｎｇ　ｅｔ　ａｌ．: Ｊ．　Ａｍ．　Ｃｈｅｍ．　Ｓｏｃ． Ｖｏｌ．１３１，　Ｎｏ．３８, ｐ．１３７０９-１３７２１（２００９）

Toru Ishikawa

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