Title:
プロテインチロシンホスファターゼ阻害剤およびその使用方法
Document Type and Number:
Japanese Patent JP2008520575
Kind Code:
A
Abstract:
The present invention provides compounds of Formula (I) and Formula (II) that are useful for modulating the biological activity of the protein tyrosine phosphatase-1b (PTP1B) enzyme. Compounds of this invention can be used to treat diseases and/or conditions in which the PTP1B enzyme is a factor. Such diseases and/or conditions include, but are not limited to, Type 1 diabetes, Type 2 diabetes, inadequate glucose tolerance, insulin resistance, obesity, hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, low HDL levels, atherosclerosis, vascular restenosis, inflammatory bowel disease, pancreatitis, adipose cell tumors, adipose cell carcinoma, liposarcoma, dyslipidemia, cancer, and neurodegenerative diseases.
Inventors:
Blaskovich, Mark A.
Bowman, Ted
Little, Thomas
Pat, Williams
Quaber, Maha
Schultz, Lauri
Hong, Feng
Nagra, gangader
Gage, Jennifer Lynn
Hobart, James Jeffrey
Bowman, Ted
Little, Thomas
Pat, Williams
Quaber, Maha
Schultz, Lauri
Hong, Feng
Nagra, gangader
Gage, Jennifer Lynn
Hobart, James Jeffrey
Application Number:
JP2007541423A
Publication Date:
June 19, 2008
Filing Date:
November 15, 2005
Export Citation:
Assignee:
CEPTYR,INC.
International Classes:
C07F9/38; A61K31/662; A61P1/04; A61P1/18; A61P3/04; A61P3/06; A61P3/10; A61P9/10; A61P25/00; A61P35/00; A61P43/00; C07F9/40; C07F9/568; C07F9/572; C07F9/59; C07F9/6509; C07F9/6533; C07F9/655
Foreign References:
| WO2000069889A1 | 2000-11-23 | |||
| WO2003041729A1 | 2003-05-22 | |||
| WO2004079012A1 | 2004-09-16 | |||
| US6348572B1 | 2002-02-19 | |||
| WO1997043307A1 | 1997-11-20 | |||
| US20020055463A1 | 2002-05-09 | |||
| WO1997008193A1 | 1997-03-06 | |||
| WO1994008600A1 | 1994-04-28 | |||
| WO2006009876A2 | 2006-01-26 | |||
| WO2006017124A2 | 2006-02-16 |
Attorney, Agent or Firm:
Hironobu Onda
Makoto Onda
Makoto Onda