Title:
PROTEIN CONJUGATE PREPARED BY USING IMMUNOGLOBULIN FRAGMENT, AND METHOD FOR PRODUCING THE SAME
Document Type and Number:
Japanese Patent JP2011256211
Kind Code:
A
Abstract:
To provide a technique useful for developing long-acting formulations of various polypeptide drugs.
There is provided a protein conjugate comprising a physiologically active polypeptide, a non-peptide polymer and an immunoglobulin Fc fragment bonded with each other through covalent bonds and having improved in vivo sustainability and stability. The in vivo activity of the physiologically active polypeptide is maintained at a relatively high level, the serum half-life of the drug is remarkably extended, and the drug has low risk of inducing immune response.
Inventors:
KIM YOUNG MIN
KIM DAE JIN
BAE SUNG MIN
LIM CHANG KI
KWON SE CHANG
LEE GWAN SUN
KIM DAE JIN
BAE SUNG MIN
LIM CHANG KI
KWON SE CHANG
LEE GWAN SUN
Application Number:
JP2011209594A
Publication Date:
December 22, 2011
Filing Date:
September 26, 2011
Export Citation:
Assignee:
HANMI HOLDINGS CO LTD
International Classes:
A61K47/42; C07K19/00; C07K14/52; C07K16/00; C07K16/42; C12N15/70; C12N15/09
Attorney, Agent or Firm:
Kenzo Hara International Patent Office
Previous Patent: SYNERGISTIC FUNGICIDAL ACTIVE COMPOUND COMBINATION
Next Patent: METHOD FOR OBTAINING BICALUTAMIDE
Next Patent: METHOD FOR OBTAINING BICALUTAMIDE