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Patent Searching and Data


Title:
PROTEIN CONSTITUTING VOLTAGE-ACTIVATED TYPE PROTON CHANNEL AND METHOD FOR UTILIZING THE SAME
Document Type and Number:
Japanese Patent JP2008289363
Kind Code:
A
Abstract:

To provide a method for industrial applications of a voltage-sensitive proton channel of mammals such as a human or a mouse which are accomplished in the course of the study for elucidating the molecular basis of the voltage-sensitive proton channel of the mammals such as the human or the mouse.

Search is made on the basis of the known sea squirt VSP (voltage-sensitive phosphatase, non-patent document 1) DNA sequence from the genome to carry out retrieval of molecules to be candidates for the proton channel of the mammals. As a result, a new cDNA exhibiting a sequence similar to the structures of S1 to S4 of a voltage-sensitive channel (figure 1) is discovered from the information about the murine and the human cDNA. The mVSOP1 (murine voltage-sensitive proton channel) cDNA is integrated into a vector and forcedly expressed in a human established cell and a current is measured. Thereby, it is concluded that the mVSOP1 is the voltage-sensitive proton channel.


Inventors:
OKAMURA YASUSHI
SASAKI MARI
Application Number:
JP2005255959A
Publication Date:
December 04, 2008
Filing Date:
September 05, 2005
Export Citation:
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Assignee:
NAT INST NATURAL SCIENCES
International Classes:
C12N15/09; C07K14/47; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12Q1/02
Attorney, Agent or Firm:
Akira Shimoda
Kenichiro Akao
Naoto Koyama