PROTEIN HAVING CELL PROLIFERATION ACCELERATING ACTION, ITS COMPOSITION AND ITS PREPARATION

Title:

PROTEIN HAVING CELL PROLIFERATION ACCELERATING ACTION, ITS COMPOSITION AND ITS PREPARATION

Document Type and Number:

Japanese Patent JPS6028999

Kind Code:

A

Abstract:

NEW MATERIAL:The protein essentially free from nucleoside phosphotransferase, and having the following characteristics. (a) Molecular weight; 5,000W160,000 determined from the relationship between the elution of the high-speed liquid chromatography and the molecular weight using thioglobin (molecular weight: 670,000), bovine γ- globulin (158,000), avian ovoalbumin (44,000), bird myoglobin (17,000) and vitamin B12 (1,350) as marker proteins, (b) composed mainly of acidic amino acid and neutral amino acid and containing relatively large amount of glutamic acid and aspartic acid as the acidic amino acid, and (c) having cell proliferation acceleration activity.

USE: Remedy for wound. The effect can be improved by the combined use of a zinc compound.

PREPARATION: A bacterial strain selected from Clostridium genus, Staphylococcus genus, Bacillus genus, etc. is cultured, and the objective protein is separated from the cultured cell or cultured liquid.

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Inventors:

FUJII SETSUO
CHIKASAWA NOBUMOTO
ARIMA AKIO
FUKUSHIMA MASAKAZU

Application Number:

JP11986383A

Publication Date:

February 14, 1985

Filing Date:

June 30, 1983

Export Citation:

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Assignee:

MARUHO KK

International Classes:

A61K31/714; A61K33/30; A61K35/74; A61K35/742; A61K35/744; A61K35/747; A61K38/00; A61P1/04; A61P1/16; A61P17/00; A61P43/00; C07K1/22; C07K14/005; C07K14/195; C07K14/21; C07K14/24; C07K14/245; C07K14/255; C12P21/00; C07K14/28; C07K14/31; C07K14/315; C07K14/32; C07K14/33; C07K14/335; C07K14/34; C07K14/41; C12R1/01; C12R1/07; C12R1/125; C12R1/145; C12R1/15; C12R1/185; C12R1/19; C12R1/20; C12R1/37; C12R1/38; C12R1/42; C12R1/425; C12R1/43; C12R1/44; C12R1/445; C12R1/45; C12R1/46; (IPC1-7): A61K31/68; A61K33/30; A61K35/74; A61K37/02; A61K39/395; C07K15/04; C12/; C12N5/00; C12P21/00; C12R1/07; C12R1/145; C12R1/15; C12R1/185; C12R1/37; C12R1/42; C12R1/425; C12R1/44; C12R1/46

Domestic Patent References:

JPS545020A	1979-01-16
JPS5424801A	1979-02-24
JPS5767591A	1982-04-24
JPS6011424A	1985-01-21
JPS58222026A	1983-12-23

Foreign References:

US4287184A

1981-09-01

Attorney, Agent or Firm:

Isao Sasaki

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