Title:
PROTEIN INTERACTING WITH IGF-1 RECEPTOR, GENE COODING THEREFOR AND THEIR USE
Document Type and Number:
Japanese Patent JP3294575
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To obtain a nucleic acid useful for the therapy, diagnosis, etc., of cancers by coding for a protein capable of binding to a specific IGF-1 receptor.
SOLUTION: This invention provides (A) a nucleic acid sequence expressed by formula I or its complementary nucleic acid sequence, (B) a nucleic acid sequence capable of coding for a peptide expressing homology to a polypeptide expressed by formula II and hybridizing one of nucleic sequences of (A) under a stringent condition, or (C) a nucleic acid selected from a group containing sequences coding for IIP-10 polypeptide having amino acid sequences coded by the sequence of (A) or (B) and capable of binding to an IGF-1 receptor by degeneration of a gene code. It is preferable to prepare a recombinant polypeptide bonded to IGF-1 receptor coded by the nucleic acid (IIP-10) and detect proliferation ability of cancer cells by using the above mentioned nucleic acid.
Inventors:
Tanya Regensa
Ralph Schumacher
Michael baitner
Ralph Schumacher
Michael baitner
Application Number:
JP34299599A
Publication Date:
June 24, 2002
Filing Date:
December 02, 1999
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
A61K45/00; A61P35/00; C07K14/435; C07K14/47; C12N15/09; C12N15/12; C12Q1/02; C12N15/00; C12Q1/68; G01N33/15; G01N33/50; G01N33/566; C12R1/91; (IPC1-7): C12N15/09; C07K14/435; C07K14/47
Attorney, Agent or Firm:
Takashi Ishida (4 others)
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