Title:
タンパク質−ポリマー−薬物共役体
Document Type and Number:
Japanese Patent JP6837035
Kind Code:
B2
Abstract:
A polymeric scaffold useful for conjugating with a protein based recognition-molecule (PBRM) to form a PBRM-polymer-drug conjugate is described herein. The scaffold includes one or more terminal maleimido groups. Also disclosed is a PBRM-polymer-drug conjugate prepared from the scaffold. Compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions are also described.
Inventors:
Smith, roger a
Damle, Nitin Kay
Yurkovetsky, Alexander Vui
Inn, Mao
Low Winger, Timothy Bee
Thomas, Joshua Dee
Stephenson, Cherry A
Grignala, Venuar
Damle, Nitin Kay
Yurkovetsky, Alexander Vui
Inn, Mao
Low Winger, Timothy Bee
Thomas, Joshua Dee
Stephenson, Cherry A
Grignala, Venuar
Application Number:
JP2018162698A
Publication Date:
March 03, 2021
Filing Date:
August 31, 2018
Export Citation:
Assignee:
Asana Biosciences, Limited Liability Company
International Classes:
A61K39/395; A61K31/40; A61K47/34; A61K47/68; A61P35/00
Foreign References:
| WO2012171020A1 |
Other References:
Molecular Cancer Therapeutics,2013年 1月,Vol.12,No.1,p38-47
Attorney, Agent or Firm:
Shoichi Okuyama
Matsushima Tetsuo
Ayako Nakamura
Satoshi Morimoto
Arihara Koichi
Matsushima Tetsuo
Ayako Nakamura
Satoshi Morimoto
Arihara Koichi