Title:
タンパク質製剤
Document Type and Number:
Japanese Patent JP5797292
Kind Code:
B2
Abstract:
The present invention relates to methods of minimizing the aggregation of BiTE® molecules in solution. In one embodiment, a method of the invention is used to minimize the aggregation of BiTE® molecules in solution. In another embodiment, a method of the invention is used to minimize the aggregation of BiTE® molecules comprising a first and a second binding site specific for the CD3 and CD19 antigens, respectively, wherein said molecule is in solution. In a specific embodiment, the present invention provides methods to minimize the aggregation of the MT103™ BiTE® molecule in solution.
Inventors:
Sharma, Monica, S.
Shah, Ambarish
Hammond, Scott
Shah, Ambarish
Hammond, Scott
Application Number:
JP2014034844A
Publication Date:
October 21, 2015
Filing Date:
February 26, 2014
Export Citation:
Assignee:
Mediemu, LRC
International Classes:
A61K39/395; A61K9/08; A61K47/12; A61K47/18; A61K47/26; A61K47/34; A61P35/00; A61P37/06; A61P43/00; C07K16/46
Domestic Patent References:
| JP2001503781A |
Foreign References:
| WO2007073499A1 | ||||
| WO2007074880A1 | ||||
| WO2005063291A1 |
Other References:
日本医薬品添加剤協会編,医薬品添加物事典2007,株式会社薬事日報社,2007年 7月25日,第1刷,第322~323頁,(「L-リジン塩酸塩」の項参照)
Attorney, Agent or Firm:
Yusuke Hiraki
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka
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