Title:
PROTEINS COMPRISING AMINO-TERMINAL PROXIMAL SHIGA TOXIN A SUBUNIT EFFECTOR REGIONS AND CELL-TARGETING IMMUNOGLOBULIN-TYPE BINDING REGIONS
Document Type and Number:
Japanese Patent JP2020089385
Kind Code:
A
Abstract:
To provide proteins used in targeted killing of target cells, delivery of exogenous materials into target cells, labeling of subcellular compartments of target cells, and diagnosis and/or treatment of a variety of conditions such as cancers, tumors, other growth abnormalities, immune disorders, and microbial infections.SOLUTION: A protein comprises an immunoglobulin-type binding region capable of specifically binding to an extracellular target biomolecule, and a Shiga toxin effector region. The immunoglobulin-type binding region and the Shiga toxin effector region are physically oriented within the protein such that the immunoglobulin-type binding region is not located proximally to the amino-terminus of the Shiga toxin effector region.SELECTED DRAWING: None
Inventors:
ERIC POMA
ERIN WILLERT
ERIN WILLERT
Application Number:
JP2020022512A
Publication Date:
June 11, 2020
Filing Date:
February 13, 2020
Export Citation:
Assignee:
MOLECULAR TEMPLATES INC
International Classes:
C12N15/62; A61K35/12; A61K35/57; A61K35/64; A61K35/65; A61K35/74; A61K35/76; A61K36/06; A61K38/16; A61K47/68; A61K48/00; A61K49/00; A61P1/04; A61P3/10; A61P5/14; A61P9/00; A61P11/06; A61P13/02; A61P17/00; A61P17/06; A61P19/00; A61P19/02; A61P25/00; A61P29/00; A61P31/00; A61P31/04; A61P31/18; A61P35/00; A61P37/02; A61P37/06; C07K14/245; C07K16/28; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/13; C12N15/31; C12N15/63; C12Q1/02
Domestic Patent References:
| JP2006502699A | 2006-01-26 | |||
| JP2008533977A | 2008-08-28 | |||
| JP2001500730A | 2001-01-23 | |||
| JP2011050388A | 2011-03-17 |
Foreign References:
| WO2003066854A1 | 2003-08-14 |
Other References:
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BLOOD, vol. 101, no. 7, JPN6021013094, 2003, pages 2557 - 2562, ISSN: 0004628733
J. IMMUNOTHER., vol. 32, no. 7, JPN6021013096, 2009, pages 689 - 702, ISSN: 0004628734
"CD20-Specific Engineered Toxin Body Demonstrates Direct Cell Kill Of Multiple B-Cell Non-Hodgkin's L", BLOOD, vol. Volume 122, Issue 21, JPN6018050554, April 2013 (2013-04-01), pages 5152, ISSN: 0004484925
INFECT. IMMUN., vol. 62, no. 3, JPN6018050556, 1994, pages 956 - 960, ISSN: 0004484926
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Attorney, Agent or Firm:
Masaki Hirota
Seiji Ozawa
Yusaku Tokai
Makoto Horiuchi
Masako Yamauchi
Shuichi Sonomoto
Akihiro Yamamura
Hiroyuki Tomita
Seiji Ozawa
Yusaku Tokai
Makoto Horiuchi
Masako Yamauchi
Shuichi Sonomoto
Akihiro Yamamura
Hiroyuki Tomita