Title:
オーキシンデグロンシステムにおけるタンパク質分解阻害剤及びその使用
Document Type and Number:
Japanese Patent JP7398704
Kind Code:
B2
Abstract:
This protein degradation inhibitor for an auxin-inducible degron system comprises a TIR1 auxin receptor antagonist. An auxin-inducible degron system kit comprises the protein degradation inhibitor for the auxin-inducible degron system, first nucleic acids encoding a TIR1 family protein, and second nucleic acids encoding a full-length or partial Aux/IAA family protein.
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Inventors:
Masato Kanemaki
Toyoaki Natsume
Kenichiro Hayashi
Toyoaki Natsume
Kenichiro Hayashi
Application Number:
JP2019557108A
Publication Date:
December 15, 2023
Filing Date:
November 08, 2018
Export Citation:
Assignee:
Inter-university research institute corporation information and systems research institute
Kake Gakuen
Kake Gakuen
International Classes:
C12N9/99; C12Q1/37
Domestic Patent References:
| JP2008187958A | ||||
| JP2018076274A | ||||
| JP2018127429A |
Foreign References:
| WO2017072816A1 |
Other References:
HAYASHI K. et al.,Rational Design of an Auxin Antagonist of the SCFTIR1 Auxin Receptor Complex,ACS Chemical Biology,2012年,Vol. 7,pp.590-598,Figure 1の化合物番号14, Figure 4の化合物番号 15(auxinole), 16(PEO-IAA), 17, 18, 19(4F-PEO-IAA), 20,
林謙一郎 他,オーキシン受容と信号伝達の分子機構 TIR1オーキシン受容体拮抗剤の分子設計,化学と生物,2012年,Vol. 50, No. 12,pp.876-882,図1のPEO-IAA, Auxinole, 880-881頁"新しいオーキシン受容体拮抗剤と分子機構作用", 図5
BLAY G. et al.,Synthesis of Functionalized Indoles with an α-Stereogenic Ketone Moiety Through an Enantioselective,Adv. Synth. Catal,2009年,Vol. 351,pp. 2433-2440,Scheme 4の式7及びTable 3のEntry 1-5, 7-9
林謙一郎 他,オーキシン受容と信号伝達の分子機構 TIR1オーキシン受容体拮抗剤の分子設計,化学と生物,2012年,Vol. 50, No. 12,pp.876-882,図1のPEO-IAA, Auxinole, 880-881頁"新しいオーキシン受容体拮抗剤と分子機構作用", 図5
BLAY G. et al.,Synthesis of Functionalized Indoles with an α-Stereogenic Ketone Moiety Through an Enantioselective,Adv. Synth. Catal,2009年,Vol. 351,pp. 2433-2440,Scheme 4の式7及びTable 3のEntry 1-5, 7-9
Attorney, Agent or Firm:
Sumio Tanai
Masato Iida
Kazuzumi Nishizawa
Shu Oikawa
Masato Iida
Kazuzumi Nishizawa
Shu Oikawa