Title:
PROTON-BINDING POLYMERS FOR ORAL ADMINISTRATION
Document Type and Number:
Japanese Patent JP2019065024
Kind Code:
A
Abstract:
To provide pharmaceutical compositions, treating methods usable for treating diseases and other metabolic conditions to which removal of protons and/or chloride ions from the gastrointestinal tract in animals including human would provide physiologically benefits such as normalization of serum bicarbonate concentrations and the blood pH in an animal, including a human, as well as methods for producing such compositions.SOLUTION: Disclosed herein is a pharmaceutical composition comprising a cross-linked amine polymer comprising an amine residue corresponding to Formula 1 wherein R, Rand Rare independently hydrogen, hydrocarbyl, or substituted hydrocarbyl in the proviso that at least one of them is not hydrogen, and the cross-linked amine polymer has (i) an equilibrium proton binding capacity of at least 5 mmol/g and a chloride ion binding capacity of at least 5 mmol/g in an aqueous simulated gastric fluid buffer containing 35 mM NaCl and 63 mM HCl at pH 1.2 and 37°C, and (ii) an equilibrium swelling ratio in deionized water of about 2 or less.SELECTED DRAWING: None
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Inventors:
GERRIT KLAERNER
ERIC F CONNOR
RANDI K GBUR
MATTHEW J KADE
PAUL H KIERSTEAD
JERRY M BUYSSE
MICHAEL J COPE
KALPESH N BIYANI
SON H NGUYEN
SCOTT M TABAKMAN
ERIC F CONNOR
RANDI K GBUR
MATTHEW J KADE
PAUL H KIERSTEAD
JERRY M BUYSSE
MICHAEL J COPE
KALPESH N BIYANI
SON H NGUYEN
SCOTT M TABAKMAN
Application Number:
JP2018233254A
Publication Date:
April 25, 2019
Filing Date:
December 13, 2018
Export Citation:
Assignee:
TRICIDA INC
International Classes:
A61K31/785; A61K9/20; A61K9/48; A61P3/00; A61P7/00; A61P13/12; C08F26/02; C08G73/02
Attorney, Agent or Firm:
Norihito Yamao
Yasushi Ochiai
Yasushi Ochiai