PROTON-BINDING POLYMERS FOR ORAL ADMINISTRATION

Title:

PROTON-BINDING POLYMERS FOR ORAL ADMINISTRATION

Document Type and Number:

Japanese Patent JP2020158530

Kind Code:

A

Abstract:

To provide pharmaceutical compositions for treating an animal, including a human, particularly proton-binding polymers for oral administration that may be used in treatment of metabolic acidosis.SOLUTION: A pharmaceutical composition comprises a crosslinked amine polymer having a ratio of chloride ion binding capacity to phosphate ion binding capacity in a Simulated Small Intestine Inorganic Buffer (SIB) of at least 2.3:1, where the buffer used for the SIB assay comprises 36 mM NaCl, 20 mM NaH2 PO4, 50 mM 2-(N-morpholino)ethanesulfonic acid (MES) buffered to pH 5.5.SELECTED DRAWING: Figure 1A

More Like This:

JP5681156	Phosphate-binding polymer preparation
JP2017513951	Improved biocide composition based on calcium fluoride and its use
JP7133219	Copolymer containing cyclic nitroxide radical and trialkoxysilyl in side chain and use thereof

Inventors:

GERRIT KLAERNER
ERIC F CONNOR
RANDI K GBUR
MATTHEW J KADE
PAUL H KIERSTEAD
JERRY M BUYSSE
MICHAEL J COPE
KALPESH N BIYANI
SON H NGUYEN
SCOTT M TABAKMAN

Application Number:

JP2020104945A

Publication Date:

October 01, 2020

Filing Date:

June 18, 2020

Export Citation:

Click for automatic bibliography generation Help

Assignee:

TRICIDA INC

International Classes:

A61K31/785; A61K9/08; A61K47/02; A61K47/20; A61K47/22; A61P3/00; A61P3/12; A61P39/02; C08F8/00; C08F26/02

Domestic Patent References:

JP2007510783A	2007-04-26
JP2007530737A	2007-11-01

Foreign References:

WO2014197725A1

2014-12-11

Attorney, Agent or Firm:

Norihito Yamao
Michiko Matsutani
Yasushi Ochiai

Previous Patent: Continuous carbon fiber bundle package

Next Patent: 終末糖化産物（ＡＧＥ）に対する抗体を使用して、がんを治療、転移性が�...