Title:
近位尿細管上皮細胞株及びその使用
Document Type and Number:
Japanese Patent JP7141688
Kind Code:
B2
Abstract:
To provide a renal proximal tubule epithelial cell accurately reflecting the feature of a proximal tubule.SOLUTION: A renal proximal tubule epithelial cell expresses Gamma-Glutamyltransferase 1(Ggt1), Tight Junction Protein ZO-1(ZO-1), E-Cadherin, β-Catenin and Megalin, has albumin uptake ability, can induce epithelial-mesenchymal transition by adding albumin or Transforming growth factor-β(TGF-β) to culture medium, and can form spheroid by three-dimensionally culturing the cell in an extracellular matrix.SELECTED DRAWING: None
Inventors:
Nobuya Sasaki
Hayato Sasaki
Hayato Sasaki
Application Number:
JP2018093479A
Publication Date:
September 26, 2022
Filing Date:
May 15, 2018
Export Citation:
Assignee:
Kitasato Institute
International Classes:
C12N5/077; C07K14/47; C07K14/705; C12N9/10; C12Q1/06
Domestic Patent References:
| JP2017501743A | ||||
| JP2017148039A | ||||
| JP2017099417A |
Foreign References:
| WO2017129598A1 |
Other References:
佐々木 隼人ほか,P-101 Trp53ノックアウトマウスを用いた新規近位尿細管上皮細胞株の樹立,第65回日本実験動物学会総会講演要旨集,2018年04月27日
American Journal of Pathology, 2001, Vol.159, No.4, pp.1465-1475
American Journal of Pathology, 2001, Vol.159, No.4, pp.1465-1475
Attorney, Agent or Firm:
Sumio Tanai
Masato Iida
Masato Iida
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