Title:
緑膿菌ＰｃｒＶ連結型抗原ワクチン
Document Type and Number:
Japanese Patent JP6998866
Kind Code:
B2
Abstract:
The present invention discloses a conjugate comprising an antigen (for example a saccharide antigen) covalently linked to a Pseudomonas aeruginosa PcrV carrier protein comprising an amino acid sequence which is at least 80% identical to the sequence of SEQ ID NO:1-4, wherein the antigen is linked (either directly or through a linker) to an amino acid residue of the P. aeruginosa PcrV carrier protein. The invention also discloses Pseudomonas aeruginosa PcrV proteins that contain glycosylation site consensus sequences.
Inventors:
Ferron, Christiane Marie-Paul Simone Jeanne
Kemular, Stephen Jochen
Kowarik, Michael Thomas
Kebatte, Julian Laurent
Kemular, Stephen Jochen
Kowarik, Michael Thomas
Kebatte, Julian Laurent
Application Number:
JP2018520162A
Publication Date:
February 04, 2022
Filing Date:
October 19, 2016
Export Citation:
Assignee:
GlaxoSmithKline Biologicals Society Anonymous
International Classes:
A61K47/64; A61K31/70; A61K31/715; A61K35/76; A61K39/00; A61K39/02; A61K39/385; A61K47/62; A61P31/00; A61P31/04; A61P37/04; C07K14/21; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/31; C12N15/62; C12N15/63; C12P21/02
Domestic Patent References:
| JP2015533511A | ||||
| JP2011514155A | ||||
| JP2008539743A | ||||
| JP2017513480A | ||||
| JP2017523794A |
Other References:
ISAR DEJBAN GOLPASHA et al,Immunization with 3-oxododecanoyl-L-homoserine lactone-r-PcrV conjugate enhances survival of mice against lethal burn infections caused by Pseudomonas aeruginosa,BOSNIAN JOURNAL OF BASIC MEDICAL SCIENCES,2015年03月,Vol. 15, No.2,p. 15-24
GREGORY P PRIEBE,VACCINES FOR PSEUDOMONAS AERUGINOSA : A LONG AND WINDING ROAD,EXPERT REVIEW OF VACCINES,英国,2014年04月25日,VOL:13, NR:4,PAGE(S):1 - 23 (507 - 519),https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521563/pdf/nihms710058.pdf,http://dx.doi.org/10.1586/14760584.2014.890053
GREGORY P PRIEBE,VACCINES FOR PSEUDOMONAS AERUGINOSA : A LONG AND WINDING ROAD,EXPERT REVIEW OF VACCINES,英国,2014年04月25日,VOL:13, NR:4,PAGE(S):1 - 23 (507 - 519),https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521563/pdf/nihms710058.pdf,http://dx.doi.org/10.1586/14760584.2014.890053
Attorney, Agent or Firm:
Hiraki International Patent Office
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